• Ixazomib Citrate

click on thumbnail to zoom
SKU: I030

Size  
Quantity:
 
Price: make selection(s)
Description
Ixazomib Citrate is a prodrug of ixazomib, a protease inhibitor used as a second-line treatment of multiple myleoma. When in its biologically active form, ixazomib can inhibit angiogensis and induce apoptosis by activating apoptotic pathways and upregulating tumor-suppressor genes.

    CAS Number

    1239908-20-3

    Molecular Formula

    C20H23BCl2N2O9

    Molecular Weight

    517.12

    Mechanism of Action

    Ixazomib is able to inhibit the chymotrypsin-like proteolytic (β5) site of the 20S proteasome, and at higher concentrations inhibit the caspase-like (β1) and trypsin-like (β2) proteolytic sites.

    Storage Conditions

    2-8°C

Specifications

    Appearance

    White Powder

    Source

    Synthetic

    Assay

    (HPLC): Not less than 98.0%

References

    References

    Offidani, M., Corvatta, L., Caraffa, P., Gentili, S., Maracci, L., & Leoni, P. (2014). An evidence-based review of ixazomib citrate and its potential in the treatment of newly diagnosed multiple myeloma. OncoTargets and Therapy, 1793. doi:10.2147/ott.s49187

Other Items In This Category