• Isoniazid packaged and labeled.

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SKU: I004

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Description

Isoniazid is a freely soluble (140 mg/mL) bactericidal and bacteriostatic anti-tuberculosis agent.

    CAS Number

    54-85-3

    Molecular Formula

    C6H7N3O

    Molecular Weight

    137.14

    Mechanism of Action

    Isoniazid acts as a prodrug which must be activated by catalase, an enzyme produced by bacteria to prevent formation of unstable oxygen radicals. Once activated, isoniazid binds to and inactivates InhA, an enoyl-reductase involved in mycolic acid synthesis.

    Storage Conditions

    ≤30°C

    Tariff Code

    2933.99.4600

    Spectrum

    Isoniazid targets Mycoplasma species including M. tuberculosis, M. bovis, and M. kansasii.

Specifications

    Appearance

    White Crystalline Powder

    pH

    6.0-8.0

    Melting Point

    170-173°C

    Assay

    (On Dried Basis): 99.0-100.5%

    Loss on Drying

    ≤0.5%

    Sulfated Ash

    ≤0.1%

    Heavy Metals

    ≤10ppm

References

    References

    Johnsson, Kai. "Studies on the Mechanism of Action of Isoniazid and Ethionamide in the Chemotherapy of Tuberculosis." American Chemical Society (1994): 5009-010. Web. 18 Oct. 2012.

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