• Isocyclosporin A, EvoPure� packaged and labeled in glass vial.

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Isocyclosporin A is a rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying cyclosporin A. The pharmacology of isocyclosporin A has received little attention.

Isocyclosporin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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    White powder



    Cyclosporin A, a peptide metabolite from Trichoderma polysporum, with remarkable immunosuppressive activity. Ruegger A. et al. Helv. Chim. Acta 1976, 59, 1075.

    Hydrolysis of cyclosporin A: Identification of 1,11 seco-cyclosporin A and 4,5 seco-isocyclosporin A by FAB-MS/MS. Magni F. et al. Peptides 1995, 16, 1335.

    Kinetics of acid-catalyzed degradation of cyclosporin A and its analogs in aqueous solution. Oliyai R. et al. Int. J. Pept. Protein Res. 1994, 43, 239.

    Kinetics and mechanism of isomerization of cyclosporin A. Oliyai R. & Stella V. J. Pharm. Res. 1992, 9, 617.

    Synthesis of a fluorescent derivative of cyclosporin A for high-performance liquid chromatography analysis. Fois R. A. & Ashley J. J. J. Pharm. Sci. 1991, 80, 363.

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