• Ingenol-3-mebutate

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SKU: I036

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Description
Ingenol-3-mebutate is an anticancer agent isolated from Euphorbia peplus used in the treatment of Actinic keratosis. Researchers have shown interest in expanding its anticancer activity, finding promise in its ability to promote proapoptotic effects in the cell while inhibiting antiapoptotic ones.

    CAS Number

    75567-37-2

    Molecular Formula

    C25H34O6

    Molecular Weight

    430.53

    Mechanism of Action

    Ingenol-3-mebutate is a modulator of the protein kinase C family.

    Storage Conditions

    -20┬░C

References

    References

    Serova, M., Ghoul, A., Benhadji, K. A., Faivre, S., Tourneau, C. L., Cvitkovic, E., . . . Raymond, E. (2008). Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.Molecular Cancer Therapeutics, 7(4), 915-922. doi:10.1158/1535-7163.mct-07-2060


    Ersvaer, E., Kittang, A. O., Hampson, P., Sand, K., Gjertsen, B. T., Lord, J. M., & Bruserud, Ø. (2010). The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity. Toxins, 2(1), 174-194. doi:10.3390/toxins2010174

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