• Indomethacin morpholinylamide

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SKU: I039

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Description
Indomethacin morpholinylamide (BML-190) is an aminoalkylindole ligand that is highly selective for cannabinoid CB2 receptor. It has demonstrated its ability to mediate lipopolysaccharide-stimulated inflammation. In addition, similar CB2 receptor agonists have been investigated for their ability to induce apoptosis.

    CAS Number

    2854-32-2

    Molecular Formula

    C23H23ClN2O4

    Molecular Weight

    426.89

References

    References

    New, D. C., & Wong, Y. H. (2003). BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: Signalling via cAMP and inositol phosphates. FEBS Letters, 536(1-3), 157-160. doi:10.1016/s0014-5793(03)00048-6

    Zhang, Q., Ma, P., Cole, R. B., & Wang, G. (2010). In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences, 41(1), 163-172. doi:10.1016/j.ejps.2010.06.004

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