• Hydroxyurea

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Description
Hydroxyurea is an antineoplastic chemotherapy drug. It is primarily known for its use in the treatment of the genetic blood disorder, sickle cell anemia, but it is also approved for the treatment of leukemia, skin cancer, and ovarian cancer.

Hydroxyurea is freely soluble in water.

    CAS Number

    127-07-1

    Molecular Formula

    CH4N2O2

    Molecular Weight

    76.05

    Mechanism of Action

    Hydroxyurea targets the ribonucleotide reductase essential to DNA synthesis, and arrests the cell cycle at S-phase.

References

    References

    Segal JB, Strouse JJ, Beach MC, et al. Hydroxyurea for the Treatment of Sickle Cell Disease. Rockville (MD): Agency for Healthcare Research and Quality (US); 2008 Feb. (Evidence Reports/Technology Assessments, No. 165.) 1, Introduction. Available from: http://www.ncbi.nlm.nih.gov/books/NBK38503/

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