Hybrid antibiotic overcomes resistance in P. aeruginosa by enhancing outer membrane penetration and reducing efflux

Gorityala et al. took an interesting look at overcoming antibiotic resistance by linking two common antibiotics together. Their hybrid antibiotic of aminoglycoside tobramycin and fluoroquinolone moxifloxacin, connected by a C12 tether, was designed to combat multi-drug resistant gram-negative bacteria Pseudomonas aeruginosa. The hybrid showed a low incidence of resistance mutations as expected from multitargetting antibiotics. It was also potent against multiple levels of drug-resistant strains of P. aeruginosa, MDR, XDR and PDR, and showed evidence of destabilization and depolarization the cell membranes.

Read more here: http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00867