• Griseofulvin packaged and labeled.

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SKU: G008

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Description

Griseofulvin is an insoluble (8.64 µg/mL) fungistatic antifungal.

    CAS Number

    126-07-8

    Molecular Formula

    C17H17ClO6

    Molecular Weight

    352.77

    Mechanism of Action

    The mechanism of action is not well described, but is currently thought to bind to tubulin and interfere with mitosis. In addition, griseofulvin is thought to inhibit synthesis of nucleic acids.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Griseofulvin targets fungi responsible for tinea infections including Microsporum, Epidermophyton, and Trichophyton species.

Specifications

    Form

    Powder

    Appearance

    White powder

    Source

    Penicillium Griseofulvum

    Melting Point

    217-224 °C

    Assay

    ≥900 µg/mg

    Loss on Drying

    ≤1.0%

References

    References

    Rice, Louis B., and Mahmoud A. Ghannoum. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance." Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.

    Santra, Manas K., and Leslie Wilson. "Kinetic Suppression of Microtubule Dynamic Instability by Griseofulvin: Implications for Its Possible Use in the Treatment of Cancer." PNAS pag. Pnas.org. 19 May 2005. Web. 22 Aug. 2012.

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