Gram-Negative Activity

Cell wall structure of Gram-negative bacteria and their susceptibility to antibiotics.

Gram-negative bacteria are a class of bacteria characterized by an outer layer of LPS (lipopolysaccharide) which does not allow retention of crystal violet stain during the Gram stain process. Gram-negative bacteria do synthesize peptidoglycan; however, the peptidolycan layer is sandwiched between an inner and outer membrane and is not directly exposed to the environment. Because of the outer LPS layer and hidden peptidoglycan layer, certain antibiotics are ineffective against Gram-negative bacteria. Well-known Gram-negative genera include Escherichia (includes E. coli), Pseudomonas, Neisseria (includes N. gonorrhoeae), Klebsiella, Proteus, Enterobacter, and Haemophilus.

The following antibiotics are effective against Gram-negative bacteria.

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Amikacin sulfate packaged and labeled.
Amikacin Sulfate is broad spectrum aminoglycoside antibiotic derived from its counterpart kanamycin A.
Amoxicillin trihydrate packaged and labeled.
Amoxicillin is an extended spectrum β-lactam antibiotic similar in structure to Ampicillin.
Ampicillin anhydrous packaged and labeled.
Ampicillin Anhydrous is a β-lactam antibiotic commonly used as a selectable marker.
Ampicillin/sulbactam (2:1) packaged and labeled.

Ampicillin/Sulbactam is a combination of a β-lactam antibiotic with a β-lactamase inhibitor. 

Chloramphenicol palmitate packaged and labeled in glass vial.
Chloramphenicol Palmitate is a prodrug of Chloramphenicol.
D-Cycloserine packaged and labeled.
D-cycloserine is an amino acid analog antibiotic. and competitive inhibitor of D-alanine.
Elaiophylin packaged and labeled in glass vial.
Elaiophylin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase...
Ertapenem sodium, EvoPure packaged and labeled.

Ertapenem sodium is broad-spectrum β-lactam carbapenem.

Erythromycin Estolate packaged and labeled.
Erythromycin Estolate, a derivative of Erythromycin, is the lauryl sulfate salt of the proprionic ester of Erythromycin.
Irgasan (Triclosan) packaged and labeled.
Irgasan (Triclosan) is a broad spectrum antibacterial agent.
Mitomycin C packaged and labeled.

Mitomycin C is a natural methylazirinopyrroloindoledione antineoplastic antibiotic isolated from Streptomyces spp that inhibits bacterial DNA synthesis.  

Nourseothricin (Streptothricin) Sulfate
Nourseothricin is an antibiotic in the Streptothricin class of antibiotics.
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