• Gilvocarcin M packaged and labeled in glass vial.

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SKU: G055

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Description
Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin M contains a methyl group in the 8-position, and is less active than the vinyl analogue (gilvocarcin V), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research suggests that the gilvocarcins act as photoactivated cross-linkers of DNA to histones.

Gilvocarcin M is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility. 

    CAS Number

    77879-89-1

    Molecular Formula

    C26H26O9

    Molecular Weight

    482.5

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow Lyophilisate

References

    References

    Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Matsumoto A. & Hanawalt P.C. Cancer Res. 2000, 60, 3921.

    Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. Balitz DM et al. . J Antibiot (Tokyo) 1981, 34, 1544-1555.

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