• TOKU-E gentamicin sulfate solution packaged and labeled.

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SKU: G046

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Description

Gentamicin sulfate solution (50 mg/mL) is an aminoglycoside antibiotic solution suitable for use in cell culture to prevent and control bacterial cell culture contamination.

Gentamicin sulfate solution (G046) contains gentamicin sulfate dissolved in water at a concentration of 50 mg/mL.

    CAS Number

    1405-41-0

    Molecular Formula

    C21H43N5O7

    Molecular Weight

    477.60

    Mechanism of Action

    Gentamicin targets the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    2-8┬░C

    Tariff Code

    3004.10.5060

Applications

    Eukaryotic Cell Culture Applications

    Gentamicin sulfate can be added to cell culture media to prevent contamination by Gram-positive and/or Gram-negative bacteria for maintaining continuous cell lines or when propagating primary cell lines.

    Microbiology Applications

    Gentamicin sulfate is commonly used as a selective agent to select for cells containing the gentamicin resistance gene, aacj-AaphD or aacC1. Gentamicin sulfate is generall used at a concentration of 10 - 20 µg/mL.

     

    Media Supplements

    Gentamicin can be used as a selective agent in several types of isolation media:

    Columbia Blood Agar - Gardnerella vaginalis Selective Supplement

    VRE Medium - VRE Selective Supplement

    Burkholderia cepacia Agar Base - Burkholderia cepacia Selective Supplement

Specifications

    Form

    Solution

    Concentration

    50mg/mL

References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides." References Microbiological Reviews 51.3 (1987): 341-50.

    Sarna, Katarzyna, and Agata Blazewicz. "Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection." PubMed (2010)

    Vydrin, A. F. "Component Composition of Gentamicin Sulfate Preparations." Pharmaceutical Chemistry Journal 37.8 (2003): 448-49. Web. 15 Oct. 2013.

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