• Geninthiocin packaged and labeled in glass vial.

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SKU: G052

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Description
Geninthiocin is a thiopeptide antibiotic isolated from a Streptomyces sp. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

Geninthiocin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

    CAS Number

    158792-27-9

    Molecular Formula

    C50H49N15O15S

    Molecular Weight

    1132.1

    Mechanism of Action

    Geninthiocin is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Amorphous Powder

References

    References

    Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84. Yun B-S. et al. J. Antibiot. 1994, 47, 969.

    Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators. Kahmann J.D. et al. EMBO J. 2003, 22, 1824.

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