• Gefitinib packaged and labeled.

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SKU: G039

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Description

Gefitinib is commonly used as an anti-lung and anti-breast cancer agent. Gefitinib acts as an inhibitor of mutated or overactive epidermal growth factor receptor (EGFR) by binding to the ATP binding site. Because epidermal growth factors are responsible for controlling cell growth and proliferation, a mutated form would likely facilitate cancer growth and development. Gefitinib is sparingly soluble in aqueous solution (0.027 mg/mL).

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    CAS Number

    184475-35-2

    Molecular Formula

    C22H24CIFN4O3

    Molecular Weight

    446.902

    Mechanism of Action

    Gefitinib is a selective inhibitor of epidermal growth factor receptor's tyrosine kinease domain. Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.

    Storage Conditions

    -20 °C

    Tariff Code

    2921.42.9000

Applications

    Cancer Applications

    EGFR is overexpressed in the cells of certain types of human carcinomas. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation.

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤0.2%

    Melting Point

    198-203°C

    Assay

    (On Dried Basis): 98.0-101.0%

References

    References

    Birnbaum, A. "Gefitinib Therapy for Non-small Cell Lung Cancer." Current Treatment Options in Oncology 6.1 (2005): 75-81. www.ncbi.gov. Jan. 2005. Web. 4 Sept. 2012.

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