SKU: G060

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GE23077 is a cyclic antimicrobial peptide isolated from Actinomadura spp.

    Molecular Formula


    Molecular Weight


    Mechanism of Action

    GE23077 inhibits transcription and protein synthesis in bacteria by binding directly to bacterial RNA polymyerase.


    GE23077 has a narrow spectrum of activity against Gram-positive and Gram-negative bacteria.

Technical Data
HPLC, NMR, FTIR, and MS analysis may be available. For more info, please email [email protected].


    Sarubbi, Edoardo, Federica Monti, Emiliana Corti, Anna Miele, and Enrico Selva. "Mode of Action of the Microbial Metabolite GE23077, a Novel Potent and Selective Inhibitor of Bacterial RNA Polymerase." European Journal of Biochemistry 271.15 (2004)

    Zhang, Yu, David Degen, Mary X. Ho, Elena Sineva, Katherine Y. Ebright, Yon W. Ebright, Vladimir Mekler, Hanif Vahedian-Movahed, Yu Feng, Ruiheng Yin, Steve Tuske, Herbert Irschik, Rolf Jansen, Sonia Maffioli, Stefano Donadio, Eddy Arnold, and Richard H. Ebright. "GE23077 Binds to the RNA Polymerase ‘i’ and ‘i 1’ Sites and Prevents the Binding of Initiating Nucleotides." ELife 3 (2014)

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