• Fluconazole packaged and labeled.

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SKU: F010

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Description

Fluconazole is an insoluble (0.001 mg/mL) fungistatic triazole antifungal. Fluconazole is a broad spectrum antimycotic targeting ergosterol synthesis in a wide range of fungal species.

    CAS Number

    86386-73-4

    Molecular Formula

    C13H12F2N6O

    Molecular Weight

    306.27

    Mechanism of Action

    Fluconazole interferes with the conversion of lanosterol to ergosterol, an essential cell membrane component. The inhibition of ergosterol synthesis increases cell permeability which disrupts normal cellular function.

    Storage Conditions

    ≤30°C

    Tariff Code

    2933.99.7500

Specifications

    Form

    Powder

    Appearance

    White or almost white crystalline powder

    Source

    Synthetic

    Impurity Profile

    Impurity A: Not more than 0.2%
    Impurity B: Not more than 0.1%
    Impurity C: Not more than 0.2%
    Total unknown impurities: Not more than 0.3%
    Total impurities: Not more than 1.5%

    Assay

    (On Dried Basis): 98.0-102.0%

    Loss on Drying

    ≤0.5%

    Residue On Ignition

    Not more than 0.1%

References

    References

    Rice, Louis B., and Mahmoud A. Ghannoum. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance." Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.

    Sobel, Jack D., and Robert A. Akins. "Fungicidal Activity of Fluconazole against Candida Albicans in a Synthetic Vagina-Simulative Medium." Antimicrobial Agents and Chemotherapy 48.1 (2004): 161-67. www.ncbi.gov. Web. 22 Aug. 2012.

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