• Faropenem sodium packaged and labeled.

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SKU: F016

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Description

Faropenem sodium is a broad spectrum beta-lactam antibiotic belonging to the penem antibiotic class. Faropenem sodium is freely soluble in water (>20mg/mL).

    CAS Number

    122547-49-3

    Molecular Formula

    C12H14NO5S • Na 

    Molecular Weight

    335.31

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like other antibiotics in the penem class, faropenem sodium is highly resistant to β-lactamases and some extended spectrum β-lactamases (ESBLs).

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Faropenem sodium is a broad spectrum antibiotic and has shown to be very effective against anaerobic pathogens known to cause oral infections.

Specifications

    Form

    Powder

    Water Content (Karl Fisher)

    ≤14.0%

    pH

    6.0-7.0

    Optical Rotation

    +145° to +150°

References

    References

    Milazzo, I. "Faropenem, a New Oral Penem: Antibacterial Activity against Selected Anaerobic and Fastidious Periodontal Isolates." Journal of Antimicrobial Chemotherapy 51.3 (2003): 721-25. Ncbi.gov. Web. 23 Jan. 2013.

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

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