SKU: E058

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Description
Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Everolimus is extensively cited in the literature with over 2,000 citations.

Everolimus is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    CAS Number

    104987-12-4

    Molecular Formula

    C43H69NO12

    Molecular Weight

    954.2

    Mechanism of Action

    Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. Hatanaka H. et al. J. Antibiot. 1988, 41, 1592.

    Identity of immunospressant FR-900520 with ascomycin. Morisaki M. & Arai T. J. Antibiot. 1992, 45, 126.

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