• Etoposide

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SKU: E066

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Description
Etoposide is an anticancer topoisomerase inhibitor that was derived from the natural product podophyllotoxin extracted from Podophyllum peltatum. It is effective against a variety of cancers, causing DNA damage which leads to apoptosis.

Etoposide is very slightly soluble in water.

    CAS Number

    33419-42-0

    Molecular Formula

    C29H32O13

    Molecular Weight

    588.56

    Mechanism of Action

    Etoposide targets DNA topoisomerase II, hindeirng the re-ligation step of DNA replication. This causes DNA damage and leads the cell to programmed cell death.

References

    References

    Montecucco, A., Zanetta, F., & Biamonti, G. (2015). Molecular mechanisms of etoposide. Experimental and Clinical Sciences, 14, 95-108. doi:10.17179/excli2015-561

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