• Erythromycin packaged and labeled.

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SKU: E002

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Description

Erythromycin is a macrolide antibiotic with a target spectrum similar to penicillin.

TOKU-E offers three forms of erythromycin: erythromycin (E002), erythromycin estolate (E003), and erythromycin ethylsuccinate (E004).  Erythromycin is sparingly soluble in aqueous solution (2 mg/mL).  Erythromycin estolate and erythromycin ethylsuccinate are both freely soluble in organic solvents.

    CAS Number

    114-07-8

    Molecular Formula

    C37H67NO13

    Molecular Weight

    733.93

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to erythromycin is commonly attributed to mutations in 50S rRNA preventing erythromycin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    <30°C

    Tariff Code

    2941.50.0000

    Spectrum

    Erythromycin is a broad spectrum antibiotic commonly targeting bacteria responsible for respiratory tract infections including Mycoplasma pneumoniae and Legionella pneumophila

Applications

    Microbiology Applications

    Erythromycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and Mycoplasma species.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Mycoplasma pneumoniae 0.0019 µg/mL – 0.0078 µg/mL
    • Legionella pneumophila 0.008 µg/mL – 1 µg/mL
    • For a  complete list of erythromycin MIC values, click here.

    Plant Biology Applications

    Erythromycin has been used in combination with nystatin and streptomycin for eliminating contaminants in rubber (Hevea brasiliensis) tissue culture (Leiffert et al.) (1991).

Specifications

    Form

    Powder

    Appearance

    White powder

    Source

    Biosynthetic: Saccharopolyspora erythraea (formerly Streptomyces erythraeus).

    Impurity Profile

    Erythromycin A||7540-22-9|C37H67NO13|733.93| Erythromycin B| 12-deoxy erythromycin|527-75-3|C37H67NO12|717.9| Erythromycin C| 3"-o-demethyl erythromycin A|1675-02-1|C36H65NO13|720.92| Erythromycin D| 3"-o-demethyl-12-deoxy erythromycin A||C36H65NO12|703.45| Impurity A| Erythromycin F|82230-93-1|C37H67NO14|749.46| Impurity B| N-demethyl erythromycin A|992-62-1|C36H65NO13|719.91| Impurity C| Erythromycin E|41451-91-6|C37H65NO14|747.91| Impurity D| Anhydroerythromycin A|23893-13-2|C37H65NO12|715.91| Impurity E| Erythromycin A enol ether|33396-29-1|C37H65NO12|715.91|

    Water Content (Karl Fischer)

    ≤10.0%

    Melting Point

    135-140°C

    Optical Rotation

    -71° to -78°

    Assay

    (On Dried Basis): 85-100.5%

References

    References

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.

    Leifert C., Ritchie J.Y. and Waites W.M., Contaminants of plant-tissue and cell cultures. World Journal of Microbiology and Biotechnology 7. 452469, 1991

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