• Erythromycin B, EvoPure packaged and labeled.

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SKU: E021

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Description

Erythromycin B, EvoPure® is a highly purified form of erythromycin B, an active component of Erythromycin.  Other components include A, C, and D.  Erythromycins B has a similar MICs to A but is slightly less active. Erythromycin B lacks a hydroxyl group at C12 that Erythromycin A has, allowing it to retain antibacterial activity in acidic environments unlike Erythromycin A.

For other Erythromycin products, click here.

    CAS Number

    527-75-3

    Molecular Formula

    C37H67NO12

    Molecular Weight

    717.92

    Mechanism of Action

    Macrolide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to erythromycin is commonly attributed to mutations in 50S rRNA preventing erythromycin binding allowing the cell to synthesize proteins free of error.

    Storage Conditions

    -20°C

    Tariff Code

    2941.50.0000

Applications

    Application

    Erythromycin B, EvoPure® can be used as a reference standard or to study the individual properties of erythromycin B. Reference standards are well characterized, highly pure compounds that can be used to help identify and/or quantify impurities in pharmaceutical compounds and antimicrobials.

Specifications

    Form

    Powder

References

    References

    Kibwage, IO et al. (1985) Antibacterial activities of erythromycins A, B, C, and D and some of their derivatives. Antimicrob. Agents Chemother 28(4): 630-33

    Tyson, Paul et al (2011) Erythromycin B: Conformational analysis and antibacterial activity. Med. Chem. Comm. 2:331-36

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