• Ertapenem sodium, EvoPure packaged and labeled.

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SKU: E008

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Description

Ertapenem sodium is a carbapenem, beta-lactam antibiotic with a broad antibacterial spectrum. Ertapenem sodium is soluble in water and sodium chloride.

    CAS Number

    153773-82-1

    Molecular Formula

    C22H24N3O7S • xNa (lot specific)

    Molecular Weight

    474.51 g/mol (Free base)

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Ertapenem sodium has broad spectrum activity targeting a wide spectrum of aerobic and anaerobic Gram positive and Gram negative bacteria.

Applications

    Microbiology Applications

    Ertapenem sodium is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Staphylococcus aureus 0.12 µg/mL – >16 µg/mL
    • Escherichia coli ≤ 0.008 - 0.5 µg/mL

    For a complete list of ertapenem MIC values, click here.

Specifications

    Appearance

    White or light yellow powder

Technical Data

HPLC, NMR, FTIR, and MS analysis may be available. For more info, please email [email protected].

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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