• Equisetin packaged and labeled in glass vial.

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SKU: E053

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Description
The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer, as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core.

Equisetin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

    CAS Number

    57749-43-6

    Molecular Formula

    C22H31NO4

    Molecular Weight

    373.5

    Storage Conditions

    -20°C

Specifications

    Appearance

    Light tan to tan solid

References

    References

    Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites. Hazuda D. et al. , Antivir. Chem. Chemother. 1999, 10, 63.

    Equisetin, an antibiotic from Fusarium equiseti NRRL 5537, identified as a derivative of N-methyl-2,4-pyrollidone. Vesonder R.F., J. Antibiot. 1979, 32, 759.

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