• Epothilone A, EvoPure� packaged and labeled in glass vial.

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SKU: E046

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Description
Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A has been investigated in clinical trials as an antitumor agent.

Epothilone A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    152044-53-6

    Molecular Formula

    C26H39NO6S

    Molecular Weight

    493.7

    Mechanism of Action

    Epothilone A acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White to off white powder

References

    References

    Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria) production, physico-chemical and biological properties. Gerth K. et al. J. Antibiot. (Tokyo) 1996, 49, 560.

    Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Bollag D. M. et al. Cancer Res. 1995, 55, 2325.

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