• Echinocandin B packaged and labeled in glass vial.

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SKU: E031

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Description
Echinocandin B is the major analogue of a family of lipopeptides isolated from several species of Aspergillus, reported in 1974. Echinocandin B is a potent antifungal.

Echinocandin B is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

    CAS Number

    54651-05-7

    Molecular Formula

    C52H81N7O16

    Molecular Weight

    1060.4

    Mechanism of Action

    Echinocandin B acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Off white to brownish powder

References

    References

    Metabolites of microorganisms. 143. Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: isolation and structural components. Nyfeler R. & Keller-Schierlein W. Helv Chim Acta. 1974, 57, 2459.

    Lysis of growing yeast-form cells of Candida albicans by echinocandin: a cytological study. Cassone A. et al. Sabouraudia 1981, 19, 97.

    Echinocandin inhibition of 1,3-beta-D-glucan synthase from Candida albicans. Sawistowska-Schröder E. T. et al. FEBS Lett. 1984, 173, 134.

    Influence of free fatty acids, lysophosphatidylcholine, platelet-activating factor, acylcarnitine, and echinocandin B on 1,3-beta-d-glucan synthase and callose synthesis. Kauss H. & Jeblick W. Plant Physiol. 1986, 80, 7.

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