• Doramectin packaged and labeled in glass vial.

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SKU: D058

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Description
Doramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.

Doramectin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    117704-25-3

    Molecular Formula

    C50H74O14

    Molecular Weight

    899.11

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Avermectin aglycones. Mrozik H. et al. J. Org. Chem. 1982, 47, 489.

    Ivermectin, a new broad-spectrum antiparasitic agent. Chabala J.C. et al. J. Med. Chem. 1980, 23, 1134.

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