• Dihydrotanshinone I

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SKU: D078

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Description
Dihydrotanshinone I is one of many bioactive products isolated from Salvia miltiorrhiza, a well-known traditional Chinese medicinal plant. It's primary promise lies in its anticancer activity, but it has been found to be active against gram-positive bacteria as well.

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    CAS Number

    87205-99-0

    Molecular Formula

    C18H14O3

    Molecular Weight

    278.3

    Mechanism of Action

    Dihydrotanshinone I initiates programmed cell death by activating caspases 3 and 9, which contribute to the degredation of cellular components.

References

    References

    Lee, D., Lee, S., Noh, J., & Hong, S. (1999). Antibacterial Activities of Cryptotanshinone and Dihydrotanshinone I from a Medicinal Herb, Salvia miltiorrhiza Bunge. Bioscience, Biotechnology, and Biochemistry, 63(12), 2236-2239. doi:10.1271/bbb.63.2236

    Lee, D., & Lee, S. (2000). Biological activity of dihydrotanshinone I: Effect on apoptosis. Journal of Bioscience and Bioengineering, 89(3), 292-293. doi:10.1016/s1389-1723(00)88838-6

    Wang, L., Hu, T., Shen, J., Zhang, L., Chan, R. L., Lu, L., . . . Wu, W. K. (2015). Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer. Phytomedicine, 22(12), 1079-1087. doi:10.1016/j.phymed.2015.08.009

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