• Derquantel packaged and labeled in glass vial.

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SKU: D046

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Description
Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel is a potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of nicotinic acetylcholine receptors acting as an antagonist of acetylcholine.

Derquantel is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    187865-22-1

    Molecular Formula

    C28H37N3O4

    Molecular Weight

    479.6

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White solid

References

    References

    Ligands of the nicotinic acetylcholine receptor as insecticides. Nauen R. et al. Pestic. Sci. 1999, 55, 608-610.

    Semisynthesis of 2-deoxo- and 3-epi-paraherquamide A. Lee B.H. et al. Bioorg. Med. Chem. Lett. 2001, 11, 553-554.

    Marcfortine and paraherquamide class of anthelmintics: Discovery of PNU-141962. Lee B.H. et al. Current Topics in Med. Chem. 2002, 2, 779.

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