• Demeclocycline hydrochloride packaged and labeled in glass vial.

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SKU: D032

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Description
Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity.

Demeclocycline hydrochloride is soluble in ethanol, methanol, DMF, DMSO, and water.

    CAS Number

    64-73-3

    Molecular Formula

    C21H22Cl2N2O8

    Molecular Weight

    501.3

    Mechanism of Action

    Demeclocycline HCl blocks protein synthesis by binding to the 30S and 50S ribosomal subunits.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Yellow to orange solid

References

    References

    A new family of antibiotics: the demethyltetracyclines. McCormack J.R.D. et al. J. Am. Chem. Soc. 1957, 79, 4561.

    Structure-activity relationships in the tetracycline series. Blackwood R.K. & English A.R. In Structure-activity relationships among the semisynthetic antibiotics. (Ed. Perlman D. Academic Press, London) 1977, 397.

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