• Demeclocycline packaged and labeled in glass vial.

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SKU: D031

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Description
Demeclocycline, a chlortetracycline analogue produced by a mutagenised strain of Streptomyces aureofaciens, was first isolated in 1957. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Demeclocycline has been extensively cited in the literature with over 800 references relating almost exclusively to in vivo use.

Demeclocycline is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    127-33-3

    Molecular Formula

    C21H21ClN2O8

    Molecular Weight

    468.9

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Yellow to orange solid

References

    References

    A new family of antibiotics: the demethyltetracyclines. McCormack J.R.D. et al. J. Am. Chem. Soc. 1957, 79, 4561.

    Structure-activity relationships in the tetracycline series. Blackwood R.K. & English A.R. In Structure-activity relationships among the semisynthetic antibiotics. (Ed. Perlman D. Academic Press, London) 1977, 397.

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