• Daptomycin packaged and labeled.

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SKU: D024

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Description

Daptomycin is a unique lipopeptide antibiotic frequently used to treat Gram-positive bacterial infections including those caused by a few drug resistant organisms. Daptomycin is soluble in water (100 mg/mL), DMSO (100 mM), methanol (mg/mL), and ethanol (50 mM).

    CAS Number

    103060-53-3

    Molecular Formula

    C72H101N17O26

    Molecular Weight

    1620.67

    Mechanism of Action

    Daptomycin peptides initially interact with anionic phospholipids in the membrane of Gram-positive bacteria. The peptides then integrate in the membrane by a calcium-mediated process and interact with membrane phospholipid head groups and acyl chains. Finally, a pore or channel is formed which can kill the cell by membrane disruption/depolarization or cellular uptake of daptomycin leading to disruption of intracellular processes.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Daptomycin targets only Gram-positive organisms including GRE (glycopeptide-resistant Enterococci) and MRSA (Methicillin Resistant Staphylococcus aureus)

    • Vancomycin resistant Enterococcus faecalis≤0.015 μg/mL - 4 μg/mL
    • Methicillin resistant Staphylcoccus aureus - 0.25 μg/mL - 2 μg/mL

    For a complete list of daptomycin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Pale Yellow to Light Brown Powder

    Source

    Streptomyces roseosporus

    Water Content (Karl Fisher)

    ≤5.0%

    Sulfated Ash

    ≤3.0%

    Heavy Metals

    ≤20ppm

References

    References

    Straus, Suzana K., and Robert E.W. Hancock. "Mode of Action of the New Antibiotic for Gram-positive Pathogens Daptomycin: Comparison with Cationic Antimicrobial Peptides and Lipopeptides." Biochimica Et Biophysica Acta (BBA) - Biomembranes 1758.9 (2006): 1215-223. Web. 24 Sept. 2013.

    "Daptomycin - Compound Summary." PubChem. N.p., n.d. Web. 24 Sept. 2013.

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