SKU: C092

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Cyclosporin, USP is a mixture of cyclic oligopeptide immunosuppressant compounds routinely given to patients after receiving an organ transplant to prevent transplant rejection. Cyclosporin, USP contains mostly cyclosporin A (>98.0%) which has the most potent immunosuppressant activity of the cyclosporins and is highly metabolized by humans and animals after ingestion. The resulting metabolites (cyclosporin B, C, D, E, H, L, and others) have been found to have less potent immunosuppressant activity and are associated with higher nephrotoxicity when compared to cyclosporin A.

TOKU-E offers purified forms of cyclosporin A, B, C, D, E, H, and L.

    CAS Number


    Molecular Formula


    Molecular Weight


    Mechanism of Action

    Cyclosporin A (CsA) immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, cyclosporin A (CsA) associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A (CsA) : cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and nitric oxide synthesis by TNFα and interleukin 1α.

    Storage Conditions

    2-8 °C


    Cancer Applications

    Cyclosporins can be used to study toxicity and immunosuppressant activity in various in vitro assays and experiments.





    White crystalline powder


    98.5-101.5% (on dried basis)

    Loss on Drying


    Heavy Metals



    Related Compounds:
    Individual impurity: ≤0.7%
    Total impurities: ≤1.5%



    Stiller, C. R., MD, and R. A. Ulan, MD. "Cyclosporin A: A Powerful Immunosuppressant."Canadian Medical Association 126 (1981): 1041-046. Web. 27 Aug. 2012.

    Crabtree, G. R., J. Nourse, and L. Timmermann. "The Mechanism of Action of Cyclosporin A and FK506." Clinical Immunology and Immunotherapy (1996): Web. 27 Aug. 2012.

    Wang, Paul C. et. al. "Isolation of 10 Cyclosporine Metabolites from Human Bile." Drug Metabolism and Disposition 17.3 (1989): 292-96. Web. 28 Oct. 2013.

    Copeland, Kenneth R. "Immunosuppressive Activity of Cyclosporine Metabolites Compared and Characterized by Mass Spectrometry and Nuclear Magnetic Resonance."Clinical Chemistry 36.2 (1990): 225-29. Web. 28 Oct. 2013.

    Matsuda, Staoshi. "Mechanisms of Action of Cyclosporine." Immunopharmacology 47 (2000): 119-25. Elsevier. Web. 28 Oct. 2013.

    Laupacis, A., and P. A. Keown. "Cyclosporin A: A Powerful Immunosuppressant." Therapeutic Review 126 (1982): 1041-046. Web. 6 Nov. 2013.

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