• Cyclopiazonic acid packaged and labeled in glass vial.

click on thumbnail to zoom
SKU: C192

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description
Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.

Cyclopiazonic acid is soluble in ethanol, methanol, DMF and DMSO.   

    CAS Number

    18172-33-3

    Molecular Formula

    C20H20N2O3

    Molecular Weight

    336.4

    Mechanism of Action

    Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.

    Storage Conditions

    -20°C

Specifications

    Appearance

    Off-white powder

References

    References

    The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling. Holzapfel C. W. Tetrahedron 1968, 24, 2101. 

    Cyclopiazonic acid and related toxins. Holzapfel C. W. In A. Ciegler, S. Kadis and S. J. Ajl (ed.) Microbial toxins, vol. VI. Academic Press Inc., New York. 1971, 435. 

    Isolation of cyclopiazonic acid, cyclopiazonic acid imine and bissecodehydrocyclopiazonic acid from the cultures of Aspergillus versicolor (Vuill.) Tiraboshi. Ohmono S. et al. J. Agric. Chem.Soc. 1973, 47, 57. 

    The acute toxicity of the mycotoxin cyclopiazonic acid to rats. Purchase I. F. H. Toxicol. Appl. Pharmacol. 1971, 18, 114. 

    Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. Seidler N. W. et al. J. Biol. Chem. 1989, 264, 17816.

Other Items In This Category