• Cyclopenin packaged and labeled in glass vial.

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SKU: C191

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Description
Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicillium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of TNF?-induced replication HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite.

Cyclopenin is soluble in ethanol, methanol, DMF or DMSO. 

    CAS Number

    19553-26-5

    Molecular Formula

    C17H14N2O3

    Molecular Weight

    294.3

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Studies in the biochemistry of microorganisms. 93. Cyclopenin, a nitrogen-containing metabolic product of Penicillium cyclopium Westling. Bracken A. et al. Biochem J. 1954, 57, 587. 

    Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumor necrosis factor alpha-induced human immunodeficiency virus replication. Heguy A. et al. Antivir. Chem. Chemother. 1998, 9, 149.

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