• Curvularin packaged and labeled in glass vial.

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SKU: C189

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Description
Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic.

Curvularin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    10140-70-2

    Molecular Formula

    C16H20O5

    Molecular Weight

    292.3

    Mechanism of Action

    Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Studies in relation to biosynthesis. Part XX. The structure and biosynthesis of curvularin. Birch J. A. et al. J. Chem. Soc. 1959, 3146. 

    Sporogen, S14-95 and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Yao Y. et al. Mol. Pharmacol. 2003, 63, 383.

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