SKU: C207

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Description
Cryptotanshinone is one of several bioactive tanshinones extracted from the Chinese medicinal herb, Salvia mitiorrhiza. It exhibits a variety of bioactivity including antibacterial, antioxidant and anti-inflammatory effects, but has more recently gained interest for its promise in the field of cancer treatment.

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    CAS Number

    35825-57-1

    Molecular Formula

    C19H20O3

    Molecular Weight

    296.36

    Mechanism of Action

    Cryptotanshinone's antitumor activity comes from its ability to inhibit STAT3 phosphorylation, which downstream inhibits cell growth promoter cyclin D1, and interferes with apoptosis inhibitors survivin and Bcl-xL.

References

    References

    Shin, D., Kim, H., Shin, K., Yoon, Y., Kim, S., Han, D., & Kwon, B. (2008) Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells. Cancer Research, 69(1), 193-202. doi:10.1158/0008-5472.CAN-08-2575

    Lee, D., Lee, S., Noh, J., & Hong, S. (1999). Antibacterial Activities of Cryptotanshinone and Dihydrotanshinone I from a Medicinal Herb, Salvia miltiorrhiza Bunge. Bioscience, Biotechnology, and Biochemistry, 63(12), 2236-2239. doi:10.1271/bbb.63.2236

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