• Coumermycin A1

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SKU: C219

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Description
Coumermycin A1 is a member of the aminocoumarin family of antibiotics, with antibacterial activity against staphylococci and other gram-positive bacteria and some select gram-negative bacteria.

    CAS Number

    4434-05-3

    Molecular Formula

    C55H59N5O20

    Molecular Weight

    1110.08

    Mechanism of Action

    Coumermycin A1 targets the B subunit of the bacterial DNA gyrase, inhibiting DNA synthesis.

Applications

    Microbiology Applications

    Coumermycin A1 is often used to select for cellswith a mutation in the gyrB gene which confers resistance to Coumermycin A1.

References

    References

    Engle, E. C., Manes, S. H., & Drlica, K. (1982). Differential Effects of Antibiotics Inhibiting Gyrase. Journal of Bacteriology, 149(1), 92–98.

    Fedorko, J., Katz, S., & Allnoch, H. (1969). In Vitro Activity of Coumermycin A1. Applied Microbiology, 18(5), 869–873.

    Samuels, D. S., Marconi, R. T., Huang, W. M., & Garon, C. F. (1994). GyrB mutations in coumermycin A1-resistant Borrelia burgdorferi. Journal of Bacteriology, 176(10), 3072–3075. doi:10.1128/jb.176.10.3072-3075.1994

    Schmutz, E., Muhlenweg, A., Li, S. ., & Heide, L. (2003). Resistance genes of Aminocoumarin producers: Two type II Topoisomerase genes confer resistance against Coumermycin A1 and Clorobiocin. Antimicrobial Agents and Chemotherapy, 47(3), 869–877. doi:10.1128/aac.47.3.869-877.2003

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