• Concanamycin B, EvoPure� packaged and labeled in glass vial.

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SKU: C183

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Description
Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A.

Concanamycin B is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    81552-33-2

    Molecular Formula

    C45H73NO14

    Molecular Weight

    851.5

    Mechanism of Action

    Concanamycin B inhibits vacuolar H(+)-ATPase and the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Structures of concanamycins B and C. Kinashi H. et al. J. Antibiot. 1982, 35, 1618.

    Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro. Woo J.T. et al. Biol. Pharm. Bull. 1996, 19, 297.

    Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Ito K. et al. J. Antibiot. 1995, 48, 488.

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