• Concanamycin A, EvoPure� packaged and labeled in glass vial.

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SKU: C182

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Description
Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.

Concanamycin A is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    80890-47-7

    Molecular Formula

    C46H75NO14

    Molecular Weight

    866.1

    Mechanism of Action

    Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Solid

References

    References

    The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells. Robinson D.G. et al. , Protoplasma 2004, 224, 255. 

    Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Kataoka T. et al. , J. Immunol. 1996, 156, 3678. 

    Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death. Nishihara T. et al. , Biochem. Biophys. Res. Commun. 1995, 212, 255. 

    Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus. Muroi M. et al. , Cell Struct. Funct. 1993, 18, 139.

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