• Cochlioquinone B, EvoPure� packaged and labeled in glass vial.

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SKU: C180

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Description
Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A which inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have recently been shown to be antagonists of the human chemokine receptor, CCR5, in HIV-1.

Cochlioquinone B is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    32450-26-3

    Molecular Formula

    C28H40O6

    Molecular Weight

    472.6

    Storage Conditions

    -20°C

Specifications

    Appearance

    Yellow Lyophilisate

References

    References

    Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum. Yoganathan K., et al. , J. Antibiot., 2004, 57, 59. 

    Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. Jung H. J. et al. , Bioorg. Med. Chem., 2003, 11, 4743. 

    Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1. Lee H. B. et al. , J. Antibiot., 2003, 56, 967. 

    Phytotoxic compounds cochlioquinones are inhibitors of mitochondrial NADH-ubiquinone reductase. Lim C.-H. et al. J. Pesticide Sci., 1996, 21, 213.

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