• Clavulanic lithium

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Clavulanate lithium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. β-lactam antibiotics, such as penicillin, can be combined with clavulanic acid for greater efficacy against β-lactam resistant strains.

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    Like other β-lactam antibiotics, the chemical structure of clavulanic acid contains a β-lactam ring allowing it to act as a β-lactamase inhibitor. By forming a covalent bond with inhibiting β-lactamase enzymes, clavulanate allows β-lactam antibiotics to bind and inhibit PBPs (penicillin binding protein) without interference from degredative enzymes.



    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

    Wise, R., J. M. Andrews, and K. A. Bedford. "In Vitro Study of Clavulanic Acid in Combination with Penicillin, Amoxycillin, and Carbenicillin." Antimicrobial Agents and Chemotherapy 13.3 (1978): 389-93. Ncbi.gov. Web. 2 Nov. 2012.

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