SKU: C175

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Description
Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium.

Cinnamycin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    110655-58-8

    Molecular Formula

    C89H125N25O25S3

    Molecular Weight

    2041.3

    Mechanism of Action

    Cinnamycin is a potent indirect inhibitor of phospholipase A2, acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane reorganisation including membrane fusion and alteration of gross morphology.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White to off white solid

References

    References

    Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin. Naruse N. J. Antibiot. 1989, 42, 837.

    Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin. Fredenhagen A. et al. J. Antibiot. 1990, 43, 1403.

    Mode of action of the lanthionine-containing peptide antibiotics duramycin, duramycin B and C, and cinnamycin as indirect inhibitors of phospholipase A2. Märki F. et al. Biochem. Pharmacol. 1991, 42, 2027.

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