• Cidofovir dihydrate

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SKU: C202

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Description
Cidofovir dihydrate is an antiviral compound and has been used clinically for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

    CAS Number

    149394-66-1

    Molecular Formula

    C8H18N3O8P

    Molecular Weight

    315.218

    Mechanism of Action

    Cidofovir targets CMV DNA polymerase and is active at a concentration of 0.1 µg/mL.

    Storage Conditions

    ≤30°C

    Spectrum

    Cidofovir dihydrate has a broad spectrum of antiviral activity against nearly all DNA viruses including poxviruses, papillomaviruses, adenoviruses, and herpesviruses. Cidofovir also targets HPV oncoproteins E6 and E7 which restores the antitumor function of p53.

Specifications

    Appearance

    White powder

    Impurity Profile

    Enantiomeric Excess: Not less than 98.0%
    HPLC: Not less than 99.0%

References

    References

    Clercq, Erik De. "Cidofovir in the Treatment of Poxvirus Infections." Antiviral Research 55.1 (2002): 1-13.

    Abdulkarim, Bassam, Siham Sabri, Eric Deutsch, Heddia Chagraoui, Laurence Maggiorella, Jerome Thierry, François Eschwege, William Vainchenker, Salem Chouaïb, and Jean Bourhis. "Antiviral Agent Cidofovir Restores P53 Function and Enhances the Radiosensitivity in HPV-associated Cancers." Oncogene 21.15 (2002): 2334-346.

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