• Chloroquine phosphate packaged and labeled.

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SKU: C142

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Description

Chloroquine phosphate is an antimalarial 4-aminoquinoline compound used to inhibit growth of malarial parasites and treat malarial infections.

    CAS Number

    50-63-5

    Molecular Formula

    C18H26ClN3 · 2H3PO4

    Molecular Weight

    515.86

    Mechanism of Action

    Chloroquine enters a malarial parasite and binds to hemozoin, a non-toxic polymer formed from the parasite in an infected red blood cell. The chloroquine:hemozin complex interferes with normal membrane function leading to build-up of chloroquine:hemozin complexes and ultimately, cell lysis.

    Storage Conditions

    2-8 °C

    Tariff Code

    2933.49.2600

    Spectrum

    Chloroquine has been shown to be effective against Plasmodium vivax, Plasmodium malariae, and some strains of Plasmodium falciparum.

Specifications

    Form

    Powder

    Appearance

    White or almost white crystalline powder

    Source

    Semi-synthetic

    pH

    3.8-4.3

    Assay

    98.5-101.0% (on dried basis)

    Loss on Drying

    ≤2.0%

    Heavy Metals

    ≤20ppm

References

    References

    Sullivan, David J. et. al. "On the Molecular Mechanism of Chloroquine's Antimalarial Action." PNAS 93 (1996): 11865-1870. Nih.gov. Web. 2 Oct. 2013.

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