• Chloramphenicol succinate packaged and labeled in glass vial.

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SKU: C169

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Description
Chloramphenicol succinate is prepared by acylation of chloramphenicol with succinic anhydride to provide a water soluble pro-drug. Chloramphenicol succinate represents an alternative pro-drug strategy for chloramphenicol that has found a niche in surface antibiotic treatment in surgery. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.

Chloramphenicol succinate is soluble in ethanol, methanol, DMF and DMSO. 

    CAS Number

    3544-94-3

    Molecular Formula

    C15H16Cl2N2O8

    Molecular Weight

    423.2

    Mechanism of Action

    After entering a bacterial cell, chloramphenicol binds to the 50S ribosomal subunit preventing peptide bond formation. Resistance to chloramphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Ambekar C.S. et al. Toxicology in vitro 2004, 18, 441.

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