Characterization of the activity of 2′-C-methylcytidine against dengue virus replication

Dengue fever is a mosquito-borne illness that does not currently have treatment options. Nucleoside analogs that inhibit viral polymerases have shown promising antiviral activity in other viruses including Hepatitus C Virus (HCV), so in this paper Lee et al. test this antimicrobial target against the dengue virus (DENV). DENV is an RNA virus, so inhibiting the viral RNA polymerase should prove to be particularly devastating to the virus's replication. 2′-C-methylcytidine (2CMC), an analog of cytidine, was tested in vivo and in vitro, and showed promising anti-DENV activity by terminating RNA chain elongation.

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