• Cercosporamide packaged and labeled in glass vial.

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SKU: C164

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Description
Cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent isolated from Cercosporidium henningsii.

Cercosporamide is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    131436-22-1

    Molecular Formula

    C16H13NO7

    Molecular Weight

    331.3

    Mechanism of Action

    Cercosporamide was shown to inhibit a cell wall integrity pathway mediated through a serine/threonine protein kinase, Pkc1, that is central to cell wall biosynthesis. It is both a potent (IC50<50nM) and selective inhibitor of Pkc1 kinase.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Light to dark tan solid

References

    References

    Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Sussman A. et al. Eukaryot Cell. 2004, 3, 932.

    Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis. Hong Z. et al. Mol. Cell Biol. 1994, 14, 1017. 

    The structure and biological activity of cercosporamide from Cercosporidium henningsii. Sugawara F. et al. J. Org. Chem. 1991, 56, 909.

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