• Ceftiofur hydrochloride

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SKU: C228

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Description
Ceftiofur sodium is a third generation cephalosporin antibiotic commonly used in veterinary medicine.  

TOKU-E Company offers two forms of ceftiofur: Ceftiofur sodium (C061) and ceftiofur hydrochloride (C228). Ceftiofur sodium is freely soluble in aqueous solution, while ceftiofur hydrochloride is insoluble in water.

    CAS Number

    103980-44-5

    Molecular Formula

    C19H17N5O7S• HCl

    Molecular Weight

    560.02

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephalosporins, ceftiofur is resistant to β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Ceftiofur is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Ceftiofur hydrochloride is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Salmonella spp. 0.5 µg/mL – 2 µg/mL
    • Escherichia coli 0.12 µg/mL – 0.5 µg/mL
    • For a complete list of ceftiofur MIC values, click here.

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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