• Cefteram pivoxil packaged and labeled.

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SKU: C144

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Description

Cefteram pivoxil is a third generation cephalosporin antibiotic. Cefteram pivoxil contains a pivoxil group which increases lipophilicity. Cefteram pivoxil is freely soluble in ethanol, acetonitrile, methanol, and chloroform.

    CAS Number

    82547-81-7

    Molecular Formula

    C22H27N9O7S2

    Molecular Weight

    593.64

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Like many third generation cephalosporins, cefteram is mostly active against gram negative bacteria especially those which cause meningitis and gonorrhea.

Specifications

    Form

    Powder

    Appearance

    Off-white or light yellow powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤2.0%

    Optical Rotation

    +35° - +43°

    Assay

    ≥98.0% (as is)

    Impurities

    Single Impurity: ≤1.5%
    Total Impurities: ≤2.0%

References

    References

    "Serious hypocarnitinemia and hypoglycaemia in Children treated with antibacterials with a Pivoxil group." Pmda.go.jp. N.p., n.d. Web. 8 Apr. 2014.

    Fuchs, Tarr. "Case Study: Cefditoren Pivoxil: An Oral Prodrug of Cefditoren." Prodrugs V (2007): 1185-194. Link.springer.com. Web. 8 Apr. 2014.

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