• Ceftazidime solubilized

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SKU: C019

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Description

Ceftazidime solubilized is a broad-spectrum, third-generation, β-lactam cephalosporin.   Patented in 1978, it came into commercial use in 1984.   It interferes with bacterial cell wall synthesis.  It is sparingly soluble in aqueous solution, but acidic and alkali solvents are commonly used to facilitate dissolution.

    CAS Number

    mixture

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases, however, ceftazidime is stable in the presence of β-lactamases.

    Storage Conditions

    2-8C

    Spectrum

    Ceftazidime is broad-spectrum, targeting both Gram-negative and Gram-positive bacteria, but is most effective for Gram-negative strains including Pseudomonas aeruginosa.  It is also used against Streptococus pneumoniae, and S. pyogenes.   It is effective against Enterobacteriaceae (including β-lactamase positive strains).

Applications

    Microbiology Applications

    Ceftazidime is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram- negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:

    • Pseudomonas aeruginosa 1 µg/mL – 64 µg/mL
    • Escherichia coli 0.06 µg/mL – >32 µg/mL
    • For a representative list of Ceftazidime MIC values, click here.

    Media Supplements

    Ceftazidime can be used as a selective agent in several types of isolation media:

    PALCAM Agar - PALCAM Selective Supplement

    ChromogenicListeria Agar - Chromogenic Listeria Selective Supplement

    ChromogenicListeria Agar - Chromogenic Listeria Differential Supplement

Specifications

    Form

    Powder

    Appearance

    white or off-white crystalline powder

    Source

    semi-synthetic

References

    References

    Fischer J, Ganellin R (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 495

    Georgopapadakou NH (1992)  Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents. Chemother. 37(3): 559-565

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