SKU: C020

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Description
Ceftazidime pentahydrate is a third generation cephalosporin antibiotic.

    CAS Number

    73547-70-3

    Molecular Formula

    C22H22N6O7S• 2HCl

    Molecular Weight

    619.505

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases, however, ceftazidime is stable in the presence of β-lactamases.

    Storage Conditions

    -20°C

    Spectrum

    Ceftazidime targets primarily gram negative bacteria especially Pseudomonas aeruginosa unlike other third generation cephalosporins.

Applications

    Microbiology Applications

    Ceftazidime is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates.

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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